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3:46
YouTube
MasterMedFacts
🧬 How HMGN1 Gene Hijacks the Heart in Trisomy 21 (Down's Syndrome) ❤️🫀🔁
🚨 New in Nature 🧬: Groundbreaking study reveals how HMGN1, a dosage-sensitive epigenetic regulator on chromosome 21, reprograms atrioventricular cardiomyocytes into a ventricular fate—driving congenital heart defects in Down syndrome 💔🫀. Using hiPSCs, single-cell RNA sequencing, and a CRISPRa CROP-seq screen, researchers pinpoint ...
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